Why waking up between 2am and 3am could actually mean something serious

A lack of magnesium can cause muscle tightness, cramps, and heightened cortisol. He explained that stiffness in the back or leg cramps—especially when pointing the toes—can be signs of deficiency.

Magnesium also supports muscle relaxation, calms the nervous system, and can help reduce anxiety and irritability. Dr. Berg recommends taking magnesium supplements in the evening before bed.

He added that magnesium levels in the body are typically lowest around 6 a.m., which may help explain why certain medical issues—such as heart attacks, strokes, and restless leg syndrome—often occur in the early morning hours.