PAD can also develop through several other mechanisms. Blood vessel inflammation, known as vasculitis, can cause vessel walls to thicken and scar. Physical traumas, including fractures and surgical procedures, can damage blood vessels and lead to PAD. Some people develop the condition from radiation exposure, particularly during cancer treatments, while others may have irregular blood vessel formation present since birth.
But here’s what’s really shocking about PAD – certain lifestyle factors and conditions can dramatically increase your risk. Smoking stands out as the single most dangerous contributor, increasing risk by 400%. Other significant risk factors include diabetes (especially Type 2), high blood pressure, and abnormal cholesterol. Age plays a crucial role, with risk climbing sharply after 65. Chronic kidney disease and a family history of cardiovascular disease also significantly increase your chances of developing PAD.
