Doctor raises alarm over popular drug: it could cause organ failure

There’s a familiar bottle in countless American medicine cabinets. It’s said to soothe pain, help you fall asleep, and ease long, restless nights. Its name is Tylenol PM. But according to one healthcare professional, those little blue pills deserve a second thought, especially if used night after night.

Dr. Ethan Melillo, a pharmacist from Rhode Island, doesn’t hold back. He’s openly stated that Tylenol PM is one of the drugs he strongly dislikes, an unusually forthright stance in the medical field. His concern isn’t that the drug doesn’t work. It’s that people often misunderstand it, assuming it’s harmless simply because it’s well-known and sold over-the-counter.

Tylenol PM: A Risky Mix of Two Ingredients
Tylenol PM is not a single drug. It’s a combination of two drugs that work together:

Paracetamol, which reduces pain and fever

Diphenhydramine, an antihistamine that causes drowsiness

At first glance, it seems convenient: pain relief and sleep aid in a single dose. But Dr. Melillo warns that this convenience can hide real risks, especially with frequent or prolonged use.