6. Blood Clots

Cancer alters the body’s clotting mechanisms. Pancreatic tumors may release substances that make blood more likely to clot. Symptoms include swelling, pain, or redness in the legs (deep vein thrombosis) or sudden shortness of breath (pulmonary embolism).

Unexplained blood clots, especially in those without a history of clotting disorders, should prompt a thorough investigation.

7. Fatigue and Weakness

Cancer drains energy in multiple ways: the body diverts nutrients to tumor growth, digestion becomes less efficient, and systemic inflammation increases fatigue. Unlike ordinary tiredness, cancer-related fatigue does not improve with rest.

If you consistently feel exhausted, weak, or unable to complete normal activities, it may be a sign that something deeper is affecting your health.

8. Itchy Skin

When bile builds up in the bloodstream due to a blocked bile duct, it can cause persistent itching. Patients often describe intense, generalized itching without a visible rash. This symptom is easily dismissed but can be a red flag when combined with jaundice or digestive changes.

When to See a Doctor

Not every case of back pain or weight loss means cancer, but combinations of these symptoms—especially if they persist for weeks—warrant medical attention. Diagnostic tools such as imaging scans, blood tests, or endoscopic procedures can identify pancreatic abnormalities early.