15 Silent Signs of Pancreatic Cancer You Need to Know

5. Unexplained Depression or Anxiety
Strangely, mood changes can sometimes precede physical symptoms. Scientists believe inflammatory chemicals released by tumors can affect brain chemistry.

Susan, 62, said she felt “off” for months—low energy, sadness, no appetite. Her depression was later linked to pancreatic dysfunction.

4. Enlarged Gallbladder or Liver
Sometimes, doctors notice an enlarged gallbladder or liver during a routine check or scan. This can be a clue that something is blocking bile flow, potentially from pancreatic changes.

While you can’t feel this yourself, you might notice bloating or pressure under the right ribs.

3. Blood Clots Without Clear Reason
Sudden swelling or pain in one leg can signal a clot. Pancreatic cancer increases the blood’s tendency to clot, sometimes before other symptoms appear.

If you develop unexplained clots or shortness of breath, don’t dismiss them—they can be early markers.

2. Pale or Oily Stools
Another subtle but telling sign—oily, foul-smelling stools that float. It indicates that your pancreas may not be releasing enough enzymes to digest fat.

Many people think it’s a diet issue, but persistent greasy stool deserves testing.

1. Persistent Indigestion or Bloating
The number one silent symptom, and the easiest to ignore. Frequent bloating, discomfort, or mild nausea after meals can indicate pancreatic strain.

David, 57, thought his symptoms were “just getting older.” After testing, his doctor found early pancreatic issues—caught in time for treatment.